What is atopy?
Called atopic genetic predisposition to develop excessive amounts of immunoglobulin E in response to contact with allergen environment. The term "atopy", which comes from the Greek word meaning "alien", first introduced AFCoca in 1922 to determine the hereditary forms of hypersensitivity to environmental factors. Manifestations of atopy are various allergic diseases and their combinations. The term "allergy" is often used as a synonym for allergic diseases, which is a mediator of immunoglobulin E, but in some patients with these diseases the levels of immunoglobulin are normal, and then released are not mediated by immunoglobulin E variant of the disease.
Atopic dermatitis
Atopic dermatitis – the most common skin diseases in infants and children, usually begins during the first 6 months of life and often continues into adulthood. Often used other terms to describe the same pathology. The most common – eczema, and even suggested a new term – "syndrome, atopic eczema / dermatitis". Earlier widely used terms such as diffuse neurodermatitis Brock, prurigo Besnier, ekzematoid, constitutional eczema, etc. In our country almost all the skin lesions in children called diathesis. Atopic dermatitis was introduced to the group of allergic diseases in 1933 on the ground that this form of eczema with bronchial asthma and allergic rhinitis. The prevalence of atopic dermatitis in all the world continues to grow, like other atopic diseases. The disease affects patients and their families, leading to sleep disturbances, psychological problems and increased financial costs.
For atopic dermatitis is characterized by an inherited predisposition to allergies, age, morphology of the eruption, phasic development and susceptibility to chronic recurrent course.
Clinical forms, depending on age
Atopic dermatitis is divided into 3 successive phases: infant, child and adult, and each has distinctive features. Infant form is observed in children from birth to 2 years. Favorite localization: a person extensor surface of limbs, may be distributed on the body. Characteristically get wet, the formation of crusts, dryness of the skin. Often exacerbated by the introduction of complementary foods and teething. Childrens form (2-12 years): skin rash primarily on the flexor surface of extremities, neck, elbow and in the popliteal pits and back of the hand. Characteristic hyperemia and edema of the skin, lihenifikatsiya (thickening and strengthening the skin of the figure), papules, plaques, erosions, cracks, scratches and peels. Cracks particularly painful in the hands and soles. It may mark the age of hyperpigmentation due to scratching, the appearance of the characteristic folds of skin under the eyes under the lower lid (Morgan-Denier line). In the adult form of juvenile released form (up to 18 years). During adolescence may be the disappearance of rash (mostly in boys), and a sharp aggravation of dermatitis with an increase in the area of lesion, lesion of the face and neck (red face syndrome), decolletage and hands of the skin around the wrists and elbows in the pits. The adult form is often continues into adulthood. Mostly defeat flexor surfaces in the natural folds, face and neck, dorsum of hands, feet, toes. Soak usually indicates the accession of secondary infection. But in any phase of the typical dry skin, itchy skin, thickening of the skin with increased skin drawing (lihenifikatsiya), desquamation, hyperemia and typical for each age rashes. Form a vicious circle: the itch – scratching – rash – itching. By the mandatory criteria of diagnosis include itching, a chronic relapsing course, atopy in the patient or relatives and typical in appearance and localization of rash. There are many additional symptoms, not mandatory, but often very bright. The diagnosis of atopic dermatitis depends on the exclusion of diseases such as scabies, allergic contact dermatitis, seborrheic dermatitis, psoriasis and ichthyosis. Leather with atopic dermatitis changed even without exacerbation and the seemingly unaltered areas of skin. Its structure and water balance violated. This requires special skin care.
Hereditary predisposition and factors, playing role in the implementation of disease
In 80% of cases family history burdened, most often through the mother, sometimes by the father, and often – on both. If atopic diseases have both parents, the risk of a child is 60-80%, if one – 45-50%, if both are healthy – 10-20%. Endogenous factors in combination with various exogenous factors lead to the development of clinical manifestations of disease.
In the first years of life atopic dermatitis is the result of food allergies. Common cause is cow’s milk proteins, eggs, cereals, fish and soy. Known advantages of breastfeeding, but must respect hypoallergenic diet nursing mother. But in some cases, when a mother suffers from severe allergies, had to use artificial feeding, infant formula based on vysokogidrolizirovannyh or partially hydrolyzed milk protein, less soy mixture.
With age, the leading role of food allergy decreases (eg, up to 90% of children do not carry cow’s milk, have the ability to endure – tolerance – to 3 years), and come to the fore allergens such as house dust mites, pollen, mold spores . Special role in the course of atopic dermatitis is staphylococcus. It is sown with 93% of the sites affected and with 76% of the intact (not changed in appearance) of the skin. Staphylococcus produces endotoxins with the properties of superantigens, and can sustain chronic inflammation in atopic dermatitis.
Atopic march
Atopic march is the natural course of development of manifestations of atopy. It is characterized by a typical sequence of development of clinical symptoms of atopic disease, when some symptoms become more pronounced, while others are declining. Usually, clinical symptoms of atopic dermatitis may precede the appearance of bronchial asthma and allergic rhinitis.According to several studies, approximately half of patients with atopic dermatitis in further developing bronchial asthma, especially if severe illness, and two-thirds – allergic rhinitis. In children with the easiest course of the disease have been reported of allergic rhinitis or bronchial asthma. The severity of atopic dermatitis can be regarded as a risk factor for bronchial asthma.According to studies in patients with severe atopic dermatitis risk of developing asthma was 70%, lung – 30%, and in general among all children – 8-10%. It is therefore important that the treatment was not only directed at the prevention of the exacerbation of atopic dermatitis, but more importantly, to prevent the development of other forms of atopic diseases.
The disease affects the quality of life of patients and their families, and also requires considerable expenditure. Studies have shown that caring for a child with atopic dermatitis associated with stressful than caring for a child with insulin-dependent diabetes mellitus.
Treatment of atopic dermatitis
At present, complete cure of atopic dermatitis is not possible. Atopic dermatitis – a chronic disease that requires long-term monitoring of the disease. A comprehensive approach to therapy. Treatment consists of selecting the most appropriate combinations of supporting basic therapy (skin care) and anti-inflammatory therapy as needed. The elimination or reduction of exposure to allergen and reduce non-allergenic effects prevents exacerbation of the disease. The effectiveness of therapy for atopic dermatitis is greatly improved if the patient education, his parents and family in the system allergoshkol.
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